![]() In August 2018, Nebraska used diazepam as part of the drug combination used to execute the first death row inmate executed in Nebraska in over 21 years. Flumazenil is also used to treat benzodiazepine overdose in adults. However, this medication can be dangerous. Flumazenil, a nonspecific competitive antagonist at the benzodiazepine receptor, can reverse benzodiazepine-induced sedation after general anesthesia, procedural sedation, and confirmed benzodiazepine overdose. Flumazenil is used to help you wake up after a surgery or medical procedure in which a benzodiazepine was used as a sedative. Flumazenil is a medication used by medical professionals when a person is experiencing a benzodiazepine overdose. Walls MD, in Rosens Emergency Medicine: Concepts and Clinical Practice, 2018 Antidote. ![]() It’s used to help execute people □ The states of California and Florida offer diazepam to condemned inmates as a pre-execution sedative as part of their lethal injection program, although the state of California has not executed a prisoner since 2006. Flumazenil (also known as flumazepil, code name Ro 15-1788 1) is a selective GABA A receptor antagonist 2 administered via injection, otic insertion, or intranasally. Flumazenil is used to reverse the effects of a benzodiazepine (BENZ-oh-dye-AYZ-e-peen) sedative such as Valium, Versed, Xanax, Tranxene, and others. The benzodiazepines are also far less dangerous death rarely results from diazepam overdose, except in cases where it is consumed with large amounts of other depressants (such as alcohol or opioids). Benzos are favorable over barbiturates □The benzodiazepines gained popularity among medical professionals as an improvement over barbiturates, which have a comparatively narrow therapeutic index, and are far more sedative at therapeutic doses. The antidote for an overdose of diazepam (or any other benzodiazepine) is flumazenil (Anexate).Ĥ. Overdose is rare, but it does happen □ Although not usually fatal when taken alone, a diazepam overdose is considered a medical emergency and generally requires the immediate attention of medical personnel. ![]() It also has many off-label indications for its use, like restless leg syndrome, acute mania, insomnia, and tardive dyskinesia. It used to make bank □ In the United States it was the highest selling medication between 19, selling more than two billion tablets in 1978 alone. Clonazepam is a benzodiazepine drug used for the acute management of the panic disorder, epilepsy, and non-convulsive status epilepticus. By mouth, effects begin after 15 to 60 minutes. Diazepam works fast □ When given into a vein, effects begin in one to five minutes and last up to an hour.
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